Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis

Abstract We investigated the feasibility of including plasma anti-NMDAR antibody screening in assessment first-episode psychosis patients an early intervention programme Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA 166 (64.0% men), matched population-based controls and 76 patients’ siblings (30.3% men). Fisher’s exact test ANOVA performed. Positive more often observed bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences observed. Our results are not conclusive regarding inclusion differential diagnostic protocols for psychosis.